Alveolar macrophages help CD8+ T cells go (anti-)viral

The human immune system is a highly complex network of cells, signals, and responses that is tightly regulated to ensure that the body can fight off infection without damaging its own tissues. Now, researchers from Japan report a new way in which the immune system protects lung tissue from viral infections.

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Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11blo to CD11bhi status during lung injury process - Mucosal Immunology

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Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung - ScienceDirect

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity - ScienceDirect

Research outcomes

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Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

Alveolar macrophage (AM) function during homeostasis or infection by

Increased innate immune activation induces protective RSV-specific lung-resident memory T cells in neonatal mice - Mucosal Immunology